Faecal microbial transplantation in ulcerative colitis
Video report of the presentation given by Prof. Eytan Wine, University of Alberta, Canada, at the Falk Symposium 190 "Challenges in the Care of IBD in Patients of all Ages" in London, October 2 - 3, 2013.
© Falk Foundation e.V., Freiburg. All rights reserved.
Depending on an individual’s genetic predisposition, gut microbes are influenced by environmental factors, such as nutrition, hygiene or infections. They are decisive for the pathogenesis of ulcerative colitis and Crohn’s disease. An innovative, promising approach to influence gut microbes is faecal microbial transplantation, which has already been found to be successful in treating Clostridium difficile infections.
A recent pilot study (Kunde et al., 2013) has shown that faecal microbial transplantations are also effective and safe in children and young adults with ulcerative colitis. In this study, faecal microbial transplantations were carried out on five consecutive days in 10 patients aged between 7 and 21 with mild to moderate ulcerative colitis. One participant was unable to hold the stool and was excluded from the study. 7 of the 9 patients showed a clinical response, which lasted for more than a month in 6 of the participants. Clinical remission was observed in 3 of the patients after one week. The faecal microbial transplantation was well tolerated and may become important in the future treatment of ulcerative colitis.