Melanosis coli 1
Length: 01:30 Min.

Melanosis coli 1


Author: Prof. em. Dr. med. S. Liebe, University Hospital Rostock, Rostock, Germany
From: Falk Media Service D34, Endoscopy Practice on Video - Selected Diseases of the Colon
2. Edition 2012. © Falk Foundation e.V. All rights reserved.


Clinical presentation
A 77-year-old white female patient was referred for colonoscopy in the work-up with iron deficiency anemia. The patient had never observed blood in her stool and testing for occult blood in the stool was negative. She reported a history of constipation for many years for which she had frequently resorted to laxatives.

Videoclip
The video recording shows various segments of the colon. The entire mucosal membrane is abnormal, exhibiting a brown, net-like discoloration. The blood vessels are recognizable in the mucosa.    

Commentary
Use of anthracene-containing laxatives over a period of many years can result in deposit of lipofuscin in the macrophages of the lamina propria. Once such laxatives are discontinued, there is a slow reduction in these deposits.

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